St. Louis Grammar School, Akure, was established by the Catholic Diocese of Ondo in January 1960 at the request of Bishop W.R. Field, SMA, with guidance from the Sisters of St. Louis from Ireland. Initially located in the St. Louis Secondary School compound in Ondo, the school moved to its current site in Akure in May 1960, starting with 32 boarding students. Thanks to the quality demanded by the Catholic Mission, its original bungalow-type structure remains functional and robust.

Brother Tom Fitzgerald, SMA, played a significant role in constructing numerous school buildings, training future artisans even before vocational education gained prominence. Over time, student numbers increased, and policies such as government takeover (1973), free education, and the closure of boarding facilities influenced its structure. With support from the Church, Government, PTA, and St. Louis Old Girls Association, the school expanded its facilities, adding lecture buildings, laboratories, staff quarters, fine art and home economics workshops, sports facilities, and computer training resources.